Fibrosis is a leading cause of morbidity and mortality worldwide, with 45% of deaths in the USA attributed to fibrotic disorders.
What is fibrosis?
Fibrosis is a pathological feature of many diseases that occurs as a result of inflammation or damage. Excessive collagen and other extracellular matrix (ECM) proteins accumulate in tissues, impairing their physiological function. Fibrosis can occur in almost any tissue and can eventually result in scarring of affected organs, leading to irreparable damage and ultimately organ failure. It has been estimated that fibrosis is prevalent in 45% of all diseases. There are no approved drugs to treat it. Fibrosis therefore represents a huge unmet clinical need.
Reference: Wynn. TA. January 2008. Cellular and molecular mechanisms of fibrosis. The Journal of Pathology. 214(2): 199-210.