The world’s first human extracellular matrix-based discovery platform.
The need for a new model for drug discovery
Just 12% of drugs that enter clinical development are ultimately successfully approved for market use. Candidates often fail due to lack of efficacy when finally tested in humans in late-stage trials. One major contributor to this high rate of failure is thought to be the limitations of current in vitro and in vivo models used in research.
Most target and drug discovery programmes rely on in vitro testing of mammalian cells grown on artificial substrates in single-layer sheets or artificial 3D substrates, which does not accurately represent the composition of human tissues and ignores the role of ECM. To improve the success rate of drug discovery, we are thinking beyond cells alone, incorporating the human extracellular matrix (ECM) into our models to recreate the natural microenvironment more closely.