The ECM in disease
As a dynamic structure, the ECM is constantly being remodelled. Changes in the composition and structure of the ECM, or genetic mutations that result in loss of control of its remodelling, can affect the phenotype of the associated cells and lead to fibrosis and cancer. The proteins that make up and regulate the remodelling of the ECM therefore represent promising therapeutic targets.
Our proprietary platform will enable preclinical and clinical studies to expose the full role of the ECM in human disease.