Science
Science
The extracellular matrix in health and disease

The extracellular matrix (ECM) is a dynamic structure that is constantly remodelled to control tissue homeostasis.

The ECM in mammals is composed of around 300 proteins, known as the core matrisome.

ECM remodelling is important during organogenesis and tissue development.

Changes in ECM composition and structure and mutations in genes that affect ECM remodelling can lead to several severe human conditions, including fibrosis and cancer.

ECM components and the proteins that regulate ECM remodelling represent promising therapeutic targets. Additional preclinical and clinical studies are required to fully understand the role of the ECM in human disease.

Our unique understanding of ECM
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Engitix has pioneered and established new protocols (proprietary patented technologies) to obtain human extracellular matrix from healthy and diseased human liver (as well as other tissues).

Engitix owns the first platform in the world based on tissue-specific and disease-specific human ECM scaffolds.

Targets discovery
in fibrosis and oncology

ECM components and the proteins that regulate ECM remodelling represent promising therapeutic targets. Additional preclinical and clinical studies are required to fully understand the role of the ECM in human disease. This is possible by using Engitix human 3D ECM platform in fibrosis and oncology.

Engitix 3D solid tumor models for testing immune oncology products

Engitix’s 3D platform can be used for testing immune oncology products such as CAR-T cells, NK cells and T cells vaccines in solid tumors 3D models: from novel target identification to functional assays.

Engitix’s 3D human ECM scaffolds are
delivered from decellularized human tissues
(proprietary and patented technologies) and
are characterized by preservation of 3D
architecture and tissue-specific biochemical
and biochemical properties.